Progesterone attenuates hemorrhagic transformation after delayed tPA treatment in an experimental model of stroke in rats: involvement of the VEGF-MMP pathway.

Won, Soonmi; Lee, Jin Hwan; Wali, Bushra; Stein, Donald G; Sayeed, Iqbal

Won, Soonmi; Lee, Jin Hwan; Wali, Bushra; Stein, Donald G; Sayeed, Iqbal.

Affiliation

Won S; Department of Emergency Medicine Brain Research Laboratory, Emory University, Atlanta, Georgia, USA.
Lee JH; Department of Anesthesiology, Emory University School of Medicine, Atlanta, Georgia, USA.
Wali B; Department of Emergency Medicine Brain Research Laboratory, Emory University, Atlanta, Georgia, USA.
Stein DG; Department of Emergency Medicine Brain Research Laboratory, Emory University, Atlanta, Georgia, USA.
Sayeed I; Department of Emergency Medicine Brain Research Laboratory, Emory University, Atlanta, Georgia, USA.

J Cereb Blood Flow Metab ; 34(1): 72-80, 2014 Jan.

Article in En | MEDLINE | ID: mdl-24045404

Subject(s)

Cerebral Hemorrhage/prevention & control; Fibrinolytic Agents/therapeutic use; Matrix Metalloproteinase 9/metabolism; Progesterone/therapeutic use; Stroke/drug therapy; Tissue Plasminogen Activator/therapeutic use; Vascular Endothelial Growth Factor A/metabolism; Animals; Blood-Brain Barrier/drug effects; Blood-Brain Barrier/pathology; Brain Edema/etiology; Brain Edema/metabolism; Brain Edema/pathology; Brain Edema/prevention & control; Capillary Permeability/drug effects; Cell Line; Cerebral Hemorrhage/etiology; Cerebral Hemorrhage/metabolism; Cerebral Hemorrhage/pathology; Disease Models, Animal; Drug Therapy, Combination; Endothelial Cells/drug effects; Endothelial Cells/pathology; Fibrinolytic Agents/administration & dosage; Fibrinolytic Agents/adverse effects; Male; Mice; Progesterone/administration & dosage; Progesterone/adverse effects; Rats; Rats, Sprague-Dawley; Signal Transduction; Stroke/complications; Stroke/metabolism; Stroke/pathology; Tight Junction Proteins/metabolism; Time Factors; Tissue Plasminogen Activator/administration & dosage; Tissue Plasminogen Activator/adverse effects; Vascular Endothelial Growth Factor A/antagonists & inhibitors

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Full text: 1 Database: MEDLINE Main subject: Progesterone / Cerebral Hemorrhage / Tissue Plasminogen Activator / Stroke / Matrix Metalloproteinase 9 / Vascular Endothelial Growth Factor A / Fibrinolytic Agents Type of study: Etiology_studies / Prognostic_studies Language: En Journal: J Cereb Blood Flow Metab Year: 2014 Type: Article Affiliation country: United States

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