Valproic acid enhances fludarabine-induced apoptosis mediated by ROS and involving decreased AKT and ATM activation in B-cell-lymphoid neoplastic cells.

Yoon, Ju-Yoon; Ishdorj, Ganchimeg; Graham, Bonnie A; Johnston, James B; Gibson, Spencer B

Yoon, Ju-Yoon; Ishdorj, Ganchimeg; Graham, Bonnie A; Johnston, James B; Gibson, Spencer B.

Affiliation

Yoon JY; Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, Canada.

Apoptosis ; 19(1): 191-200, 2014 Jan.

Article in En | MEDLINE | ID: mdl-24057147

Subject(s)

Antineoplastic Agents/administration & dosage; Apoptosis/drug effects; Ataxia Telangiectasia Mutated Proteins/metabolism; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy; Proto-Oncogene Proteins c-akt/metabolism; Reactive Oxygen Species/metabolism; Valproic Acid/administration & dosage; Vidarabine/analogs & derivatives; Adult; Ataxia Telangiectasia Mutated Proteins/genetics; Drug Synergism; Enzyme Activation/drug effects; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell/enzymology; Leukemia, Lymphocytic, Chronic, B-Cell/metabolism; Leukemia, Lymphocytic, Chronic, B-Cell/physiopathology; Male; Middle Aged; Proto-Oncogene Proteins c-akt/genetics; Tumor Cells, Cultured; Up-Regulation; Vidarabine/administration & dosage

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Full text: 1 Database: MEDLINE Main subject: Vidarabine / Leukemia, Lymphocytic, Chronic, B-Cell / Valproic Acid / Reactive Oxygen Species / Apoptosis / Proto-Oncogene Proteins c-akt / Ataxia Telangiectasia Mutated Proteins / Antineoplastic Agents Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Apoptosis Year: 2014 Type: Article Affiliation country: Canada

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