Identification of FHL1 as a therapeutic target for Duchenne muscular dystrophy.

D'Arcy, Colleen E; Feeney, Sandra J; McLean, Catriona A; Gehrig, Stefan M; Lynch, Gordon S; Smith, Jaclyn E; Cowling, Belinda S; Mitchell, Christina A; McGrath, Meagan J

D'Arcy, Colleen E; Feeney, Sandra J; McLean, Catriona A; Gehrig, Stefan M; Lynch, Gordon S; Smith, Jaclyn E; Cowling, Belinda S; Mitchell, Christina A; McGrath, Meagan J.

Affiliation

D'Arcy CE; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.

Hum Mol Genet ; 23(3): 618-36, 2014 Feb 01.

Article in En | MEDLINE | ID: mdl-24087791

Subject(s)

Intracellular Signaling Peptides and Proteins/genetics; LIM Domain Proteins/genetics; Muscle Proteins/genetics; Muscular Dystrophy, Duchenne/genetics; Muscular Dystrophy, Duchenne/physiopathology; Animals; Diaphragm/physiopathology; Dystrophin/genetics; Gene Expression Regulation; Humans; Intracellular Signaling Peptides and Proteins/metabolism; LIM Domain Proteins/metabolism; Mice; Mice, Inbred mdx; Mice, Transgenic; Muscle Contraction; Muscle Proteins/metabolism; Muscle, Skeletal/physiopathology; NFATC Transcription Factors/genetics; NFATC Transcription Factors/metabolism; Promoter Regions, Genetic; Sarcolemma/metabolism; Signal Transduction; Utrophin/genetics; Utrophin/metabolism

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Full text: 1 Database: MEDLINE Main subject: Muscular Dystrophy, Duchenne / Intracellular Signaling Peptides and Proteins / LIM Domain Proteins / Muscle Proteins Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2014 Type: Article Affiliation country: Australia

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