On the histone lysine methyltransferase activity of fungal metabolite chaetocin.

Cherblanc, Fanny L; Chapman, Kathryn L; Reid, Jim; Borg, Aaron J; Sundriyal, Sandeep; Alcazar-Fuoli, Laura; Bignell, Elaine; Demetriades, Marina; Schofield, Christopher J; DiMaggio, Peter A; Brown, Robert; Fuchter, Matthew J

Cherblanc, Fanny L; Chapman, Kathryn L; Reid, Jim; Borg, Aaron J; Sundriyal, Sandeep; Alcazar-Fuoli, Laura; Bignell, Elaine; Demetriades, Marina; Schofield, Christopher J; DiMaggio, Peter A; Brown, Robert; Fuchter, Matthew J.

Affiliation

Cherblanc FL; Department of Chemistry, Imperial College London , South Kensington Campus, London SW7 2AZ, United Kingdom.

J Med Chem ; 56(21): 8616-25, 2013 Nov 14.

Article in En | MEDLINE | ID: mdl-24099080

Subject(s)

Chaetomium/chemistry; Enzyme Inhibitors/pharmacology; Histone-Lysine N-Methyltransferase/antagonists & inhibitors; Chaetomium/metabolism; Dose-Response Relationship, Drug; Enzyme Inhibitors/chemistry; Enzyme Inhibitors/metabolism; Histone-Lysine N-Methyltransferase/metabolism; Humans; Models, Molecular; Molecular Conformation; Piperazines/chemistry; Piperazines/metabolism; Piperazines/pharmacology; Recombinant Proteins/metabolism; Structure-Activity Relationship

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Full text: 1 Database: MEDLINE Main subject: Chaetomium / Histone-Lysine N-Methyltransferase / Enzyme Inhibitors Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2013 Type: Article Affiliation country: United kingdom

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