Bleomycin inhibits adipogenesis and accelerates fibrosis in the subcutaneous adipose layer through TGF-ß1.

Ohgo, Shiro; Hasegawa, Seiji; Hasebe, Yuichi; Mizutani, Hiroshi; Nakata, Satoru; Akamatsu, Hirohiko

Ohgo, Shiro; Hasegawa, Seiji; Hasebe, Yuichi; Mizutani, Hiroshi; Nakata, Satoru; Akamatsu, Hirohiko.

Affiliation

Ohgo S; Research Laboratories, Nippon Menard Cosmetic Co., Ltd., Nagoya, Japan.

Exp Dermatol ; 22(11): 769-71, 2013 Nov.

Article in En | MEDLINE | ID: mdl-24118261

Subject(s)

Adipogenesis/drug effects; Adipose Tissue/metabolism; Bleomycin/chemistry; Fibrosis/metabolism; Transforming Growth Factor beta1/metabolism; Adipocytes/cytology; Animals; Antibiotics, Antineoplastic/chemistry; Cell Differentiation; Collagen/biosynthesis; Culture Media, Conditioned/chemistry; Disease Models, Animal; Fibroblasts/cytology; Fibroblasts/metabolism; Fibrosis/pathology; Humans; Mice; Scleroderma, Systemic/pathology; Skin/drug effects; Skin/metabolism; Skin/pathology

Key words

TGF-ß1; adipogenesis; bleomycin; skin fibrosis; systemic sclerosis

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Full text: 1 Database: MEDLINE Main subject: Bleomycin / Fibrosis / Adipose Tissue / Adipogenesis / Transforming Growth Factor beta1 Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Exp Dermatol Journal subject: DERMATOLOGIA Year: 2013 Type: Article Affiliation country: Japan

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