Inhibition of autophagy augments chemotherapy in human salivary adenoid cystic carcinoma.

Jiang, Licheng; Huang, Shengyun; Zhang, Dongsheng; Zhang, Bin; Li, Keyi; Li, Wengang; Zhang, Shizhou; Zhang, Weidong; Zheng, Peihui

Jiang, Licheng; Huang, Shengyun; Zhang, Dongsheng; Zhang, Bin; Li, Keyi; Li, Wengang; Zhang, Shizhou; Zhang, Weidong; Zheng, Peihui.

Affiliation

Jiang L; Department of Oral and Maxillofacial Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, China.

J Oral Pathol Med ; 43(4): 265-72, 2014 Apr.

Article in En | MEDLINE | ID: mdl-24118359

Subject(s)

Antineoplastic Agents/therapeutic use; Autophagy/drug effects; Carcinoma, Adenoid Cystic/drug therapy; Salivary Gland Neoplasms/drug therapy; Adaptor Proteins, Signal Transducing/analysis; Adenine/analogs & derivatives; Adenine/pharmacology; Animals; Apoptosis/drug effects; Apoptosis Regulatory Proteins/genetics; Beclin-1; Carcinoma, Adenoid Cystic/pathology; Caspase 3/analysis; Cell Line, Tumor; Cisplatin/therapeutic use; Drug Resistance, Neoplasm; Humans; Membrane Proteins/genetics; Mice; Mice, Nude; Microtubule-Associated Proteins/analysis; Neoplasm Transplantation; Plasmids/genetics; Proto-Oncogene Proteins c-bcl-2/drug effects; Proto-Oncogene Proteins c-bcl-2/genetics; RNA, Small Interfering/genetics; Salivary Gland Neoplasms/pathology; Sequestosome-1 Protein; Transfection; Xenograft Model Antitumor Assays

Key words

DDP; adenoid cystic carcinoma; apoptosis; autophagy

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Full text: 1 Database: MEDLINE Main subject: Autophagy / Salivary Gland Neoplasms / Carcinoma, Adenoid Cystic / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Oral Pathol Med Journal subject: ODONTOLOGIA / PATOLOGIA Year: 2014 Type: Article Affiliation country: China

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