Forward genetics defines Xylt1 as a key, conserved regulator of early chondrocyte maturation and skeletal length.

Mis, Emily K; Liem, Karel F; Kong, Yong; Schwartz, Nancy B; Domowicz, Miriam; Weatherbee, Scott D

Mis, Emily K; Liem, Karel F; Kong, Yong; Schwartz, Nancy B; Domowicz, Miriam; Weatherbee, Scott D.

Affiliation

Mis EK; Department of Genetics, Yale University, New Haven, CT 06520, United States.

Dev Biol ; 385(1): 67-82, 2014 Jan 01.

Article in En | MEDLINE | ID: mdl-24161523

Subject(s)

Bone and Bones/embryology; Chondrocytes/metabolism; Osteogenesis/genetics; Pentosyltransferases/physiology; Animals; Base Sequence; Bone and Bones/metabolism; Cell Differentiation/genetics; Cell Proliferation; Dwarfism/genetics; Fibroblast Growth Factors/metabolism; Hedgehog Proteins/metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation, Missense; Parathyroid Hormone-Related Protein/metabolism; Pentosyltransferases/genetics; Sequence Analysis, DNA; Signal Transduction/genetics; UDP Xylose-Protein Xylosyltransferase

Key words

CSPGs; Chondrocytes; Dwarfism; Forward genetics; Glycosaminoglycans; HSPGs; Proteoglycans; Skeletal development; Xylt1

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Full text: 1 Database: MEDLINE Main subject: Osteogenesis / Pentosyltransferases / Bone and Bones / Chondrocytes Type of study: Prognostic_studies Limits: Animals Language: En Journal: Dev Biol Year: 2014 Type: Article Affiliation country: United States

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