Different mtDNA mutations modify tumor progression in dependence of the degree of respiratory complex I impairment.

Iommarini, Luisa; Kurelac, Ivana; Capristo, Mariantonietta; Calvaruso, Maria Antonietta; Giorgio, Valentina; Bergamini, Christian; Ghelli, Anna; Nanni, Patrizia; De Giovanni, Carla; Carelli, Valerio; Fato, Romana; Lollini, Pier Luigi; Rugolo, Michela; Gasparre, Giuseppe; Porcelli, Anna Maria

Iommarini, Luisa; Kurelac, Ivana; Capristo, Mariantonietta; Calvaruso, Maria Antonietta; Giorgio, Valentina; Bergamini, Christian; Ghelli, Anna; Nanni, Patrizia; De Giovanni, Carla; Carelli, Valerio; Fato, Romana; Lollini, Pier Luigi; Rugolo, Michela; Gasparre, Giuseppe; Porcelli, Anna Maria.

Affiliation

Iommarini L; Dipartimento di Farmacia e Biotecnologie (FABIT).

Hum Mol Genet ; 23(6): 1453-66, 2014 Mar 15.

Article in En | MEDLINE | ID: mdl-24163135

Subject(s)

DNA, Mitochondrial/genetics; Electron Transport Complex I/genetics; Energy Metabolism; NADH Dehydrogenase/metabolism; Osteosarcoma/genetics; RNA, Transfer/genetics; AMP-Activated Protein Kinases/metabolism; Cell Line, Tumor; Disease Progression; Electron Transport Complex I/metabolism; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism; Mitochondrial Proteins/genetics; Mitochondrial Proteins/metabolism; Mutagenesis, Insertional; NADH Dehydrogenase/genetics; Osteosarcoma/pathology; Oxidative Phosphorylation; Point Mutation; Reactive Oxygen Species/metabolism

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Full text: 1 Database: MEDLINE Main subject: DNA, Mitochondrial / RNA, Transfer / Osteosarcoma / Electron Transport Complex I / Energy Metabolism / NADH Dehydrogenase Limits: Humans Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2014 Type: Article

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