Candesartan reduces the hemorrhage associated with delayed tissue plasminogen activator treatment in rat embolic stroke.

Ishrat, Tauheed; Pillai, Bindu; Ergul, Adviye; Hafez, Sherif; Fagan, Susan C

Ishrat, Tauheed; Pillai, Bindu; Ergul, Adviye; Hafez, Sherif; Fagan, Susan C.

Affiliation

Ishrat T; Charlie Norwood VA Medical Center, Augusta, GA, USA.

Neurochem Res ; 38(12): 2668-77, 2013 Dec.

Article in En | MEDLINE | ID: mdl-24194350

Subject(s)

Angiotensin II Type 1 Receptor Blockers/therapeutic use; Benzimidazoles/therapeutic use; Embolism/complications; Stroke/drug therapy; Tetrazoles/therapeutic use; Tissue Plasminogen Activator/therapeutic use; Animals; Biphenyl Compounds; Blotting, Western; Enzyme Activation; Male; Matrix Metalloproteinase 3/metabolism; Matrix Metalloproteinase 9/metabolism; NF-kappa B/metabolism; Nitric Oxide Synthase Type III/metabolism; Rats; Rats, Wistar; Stroke/etiology; Tumor Necrosis Factor-alpha/metabolism

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Full text: 1 Database: MEDLINE Main subject: Tetrazoles / Benzimidazoles / Tissue Plasminogen Activator / Stroke / Angiotensin II Type 1 Receptor Blockers / Embolism Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Neurochem Res Year: 2013 Type: Article Affiliation country: United States

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