Dynamics of TET family expression in porcine preimplantation embryos is related to zygotic genome activation and required for the maintenance of NANOG.

Lee, Kiho; Hamm, Jennifer; Whitworth, Kristin; Spate, Lee; Park, Kwang-Wook; Murphy, Clifton N; Prather, Randall S

Lee, Kiho; Hamm, Jennifer; Whitworth, Kristin; Spate, Lee; Park, Kwang-Wook; Murphy, Clifton N; Prather, Randall S.

Affiliation

Lee K; Division of Animal Sciences, Animal Science Research Center, University of Missouri, Columbia, MO 65201, USA. Electronic address: leekil@missouri.edu.
Hamm J; Division of Animal Sciences, Animal Science Research Center, University of Missouri, Columbia, MO 65201, USA.
Whitworth K; Division of Animal Sciences, Animal Science Research Center, University of Missouri, Columbia, MO 65201, USA.
Spate L; Division of Animal Sciences, Animal Science Research Center, University of Missouri, Columbia, MO 65201, USA.
Park KW; Division of Animal Sciences, Animal Science Research Center, University of Missouri, Columbia, MO 65201, USA; Department of Animal Science and Technology, Sunchon National University, Suncheon, Jeonnam 540-742, South Korea.
Murphy CN; Division of Animal Sciences, Animal Science Research Center, University of Missouri, Columbia, MO 65201, USA.
Prather RS; Division of Animal Sciences, Animal Science Research Center, University of Missouri, Columbia, MO 65201, USA; National Swine Resource and Research Center, University of Missouri, Columbia, MO 65201, USA.

Dev Biol ; 386(1): 86-95, 2014 Feb 01.

Article in En | MEDLINE | ID: mdl-24315853

Subject(s)

Blastocyst/metabolism; DNA-Binding Proteins/genetics; Gene Expression Regulation, Developmental; Homeodomain Proteins/metabolism; Proto-Oncogene Proteins/genetics; Animals; Dioxygenases/genetics; Fertilization; Fertilization in Vitro; Humans; Immunohistochemistry; Mice; Mixed Function Oxygenases; Multigene Family; Nanog Homeobox Protein; Nuclear Transfer Techniques; Oocytes/cytology; RNA, Messenger/metabolism; Species Specificity; Swine; Zygote/metabolism

Key words

5-hydroxymethylcytosine; 5-methylcytosine; 5hmec; 5mec; DNA methylation; DNA methyltransferases; DNMT; ICM; IVF; In vitro fertilization; MZT; Maternal to zygotic transition; Porcine embryos; SCNT; TE; TET; Ten-eleven translocation family; ZGA; inner cell mass; maternal to zygotic transition; somatic cell nuclear transfer; ten-eleven translocation; trophectoderm; zygotic genome activation

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Full text: 1 Database: MEDLINE Main subject: Blastocyst / Proto-Oncogene Proteins / Homeodomain Proteins / Gene Expression Regulation, Developmental / DNA-Binding Proteins Limits: Animals / Humans Language: En Journal: Dev Biol Year: 2014 Type: Article

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