Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762.

Chaidos, Aristeidis; Caputo, Valentina; Gouvedenou, Katerina; Liu, Binbin; Marigo, Ilaria; Chaudhry, Mohammed Suhail; Rotolo, Antonia; Tough, David F; Smithers, Nicholas N; Bassil, Anna K; Chapman, Trevor D; Harker, Nicola R; Barbash, Olena; Tummino, Peter; Al-Mahdi, Niam; Haynes, Andrea C; Cutler, Leanne; Le, BaoChau; Rahemtulla, Amin; Roberts, Irene; Kleijnen, Maurits; Witherington, Jason J; Parr, Nigel J; Prinjha, Rab K; Karadimitris, Anastasios

Chaidos, Aristeidis; Caputo, Valentina; Gouvedenou, Katerina; Liu, Binbin; Marigo, Ilaria; Chaudhry, Mohammed Suhail; Rotolo, Antonia; Tough, David F; Smithers, Nicholas N; Bassil, Anna K; Chapman, Trevor D; Harker, Nicola R; Barbash, Olena; Tummino, Peter; Al-Mahdi, Niam; Haynes, Andrea C; Cutler, Leanne; Le, BaoChau; Rahemtulla, Amin; Roberts, Irene; Kleijnen, Maurits; Witherington, Jason J; Parr, Nigel J; Prinjha, Rab K; Karadimitris, Anastasios.

Affiliation

Chaidos A; Centre for Haematology, Department of Medicine, Hammersmith Hospital, Imperial College London, London, United Kingdom;

Blood ; 123(5): 697-705, 2014 Jan 30.

Article in En | MEDLINE | ID: mdl-24335499

Subject(s)

Antineoplastic Agents/therapeutic use; Benzodiazepines/therapeutic use; Heterocyclic Compounds, 4 or More Rings/therapeutic use; Multiple Myeloma/drug therapy; Animals; Antineoplastic Agents/pharmacology; Apoptosis/drug effects; Benzodiazepines/pharmacology; Cell Cycle Checkpoints/drug effects; Down-Regulation/drug effects; Heterocyclic Compounds, 4 or More Rings/pharmacology; Humans; Mice; Multiple Myeloma/genetics; Multiple Myeloma/pathology; Proto-Oncogene Proteins c-myc/genetics; RNA-Binding Proteins/genetics; Transcription Factors; Transcriptional Activation/drug effects; Tumor Cells, Cultured

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Full text: 1 Database: MEDLINE Main subject: Benzodiazepines / Heterocyclic Compounds, 4 or More Rings / Multiple Myeloma / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Blood Year: 2014 Type: Article

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