Dioxatricyclic and oxabicyclic polyketides from Trichocladium opacum.
J Nat Prod
; 77(1): 9-14, 2014 Jan 24.
Article
in En
| MEDLINE
| ID: mdl-24354429
ABSTRACT
Five new polyketides, trichocladinols D-H (1-5) with dioxatricyclic (1-3) and oxabicyclic (4 and 5) skeletons, and the known massarilactone C (6) were isolated from the solid-substrate fermentation cultures of the ascomycete fungus Trichocladium opacum. The structures of 1-5 were determined mainly by NMR experiments, and 1, 3, and 4 were confirmed by X-ray crystallography. The absolute configurations of 1 and 3 were assigned by X-ray crystallography using Cu Kα radiation, whereas that of C-5 in 2 and 4 was deduced via the circular dichroism (CD) data. Compounds 2-4 showed weak cytotoxicity against the human tumor cell lines A549, HCT116, and SW480.
Full text:
1
Database:
MEDLINE
Main subject:
Ascomycota
/
Heterocyclic Compounds, Bridged-Ring
/
Polyketides
/
Antineoplastic Agents
Limits:
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
J Nat Prod
Year:
2014
Type:
Article