Vertical blockade of the IGFR- PI3K/Akt/mTOR pathway for the treatment of hepatocellular carcinoma: the role of survivin.

Ou, Da-Liang; Lee, Bin-Shyun; Lin, Liang-In; Liou, Jun-Yang; Liao, Sheng-Chieh; Hsu, Chiun; Cheng, Ann-Lii

Ou, Da-Liang; Lee, Bin-Shyun; Lin, Liang-In; Liou, Jun-Yang; Liao, Sheng-Chieh; Hsu, Chiun; Cheng, Ann-Lii.

Affiliation

Hsu C; Graduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei, Taiwan. hsuchiun@gmail.com.

Mol Cancer ; 13: 2, 2014 Jan 03.

Article in En | MEDLINE | ID: mdl-24387108

Subject(s)

Antineoplastic Agents/pharmacology; Antineoplastic Combined Chemotherapy Protocols/pharmacology; Carcinoma, Hepatocellular/metabolism; Inhibitor of Apoptosis Proteins/metabolism; Liver Neoplasms/metabolism; Signal Transduction/drug effects; Animals; Apoptosis/drug effects; Biomarkers, Tumor/metabolism; Blotting, Western; Cell Line, Tumor; Cell Survival/drug effects; Drug Synergism; Enzyme Inhibitors/pharmacology; Everolimus; Flow Cytometry; Heterocyclic Compounds, 3-Ring/pharmacology; Humans; Imidazoles/pharmacology; Male; Mice, Inbred BALB C; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt/antagonists & inhibitors; Pyrimidines/pharmacology; Pyrroles/pharmacology; Quinolines/pharmacology; Receptors, Somatomedin/antagonists & inhibitors; Sirolimus/analogs & derivatives; Sirolimus/pharmacology; Survivin; TOR Serine-Threonine Kinases/antagonists & inhibitors; Xenograft Model Antitumor Assays

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Signal Transduction / Antineoplastic Combined Chemotherapy Protocols / Carcinoma, Hepatocellular / Inhibitor of Apoptosis Proteins / Liver Neoplasms / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Mol Cancer Journal subject: NEOPLASIAS Year: 2014 Type: Article

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google