Sublingual immunization with a subunit influenza vaccine elicits comparable systemic immune response as intramuscular immunization, but also induces local IgA and TH17 responses.
Vaccine
; 32(20): 2382-8, 2014 Apr 25.
Article
in En
| MEDLINE
| ID: mdl-24434044
ABSTRACT
Influenza is a vaccine-preventable disease that remains a major health problem world-wide. Needle and syringe are still the primary delivery devices, and injection of liquid vaccine into the muscle is still the primary route of immunization. Vaccines could be more convenient and effective if they were delivered by the mucosal route. Elicitation of systemic and mucosal innate and adaptive immune responses, such as pathogen neutralizing antibodies (including mucosal IgA at the site of pathogen entry) and CD4(+) T-helper cells (especially the Th17 subset), have a critical role in vaccine-mediated protection. In the current study, a sublingual subunit influenza vaccine formulated with or without mucosal adjuvant was evaluated for systemic and mucosal immunogenicity and compared to intranasal and intramuscular vaccination. Sublingual administration of adjuvanted influenza vaccine elicited comparable antibody titers to those elicited by intramuscular immunization with conventional influenza vaccine. Furthermore, influenza-specific Th17 cells or neutralizing mucosal IgA were detected exclusively after mucosal immunization.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Administration, Sublingual
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Influenza Vaccines
/
Vaccination
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Orthomyxoviridae Infections
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Th17 Cells
Limits:
Animals
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Female
/
Humans
Language:
En
Journal:
Vaccine
Year:
2014
Type:
Article