Nonmuscle myosin II is a critical regulator of clathrin-mediated endocytosis.
Traffic
; 15(4): 418-32, 2014 Apr.
Article
in En
| MEDLINE
| ID: mdl-24443954
ABSTRACT
Variable requirements for actin during clathrin-mediated endocytosis (CME) may be related to regional or cellular differences in membrane tension. To compensate, local regulation of force generation may be needed to facilitate membrane curving and vesicle budding. Force generation is assumed to occur primarily through actin polymerization. Here we examine the role of myosin II using loss of function experiments. Our results indicate that myosin II acts on cortical actin scaffolds primarily in the plane of the plasma membrane (bottom arrow) to generate changes that are critical for enhancing CME progression.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Clathrin
/
Myosin Type II
/
Endocytosis
Limits:
Animals
Language:
En
Journal:
Traffic
Journal subject:
FISIOLOGIA
Year:
2014
Type:
Article
Affiliation country:
United States