Epigallocatechin 3-O-gallate induces 67 kDa laminin receptor-mediated cell death accompanied by downregulation of ErbB proteins and altered lipid raft clustering in mammary and epidermoid carcinoma cells.

Mocanu, Maria-Magdalena; Ganea, Constanta; Georgescu, Laura; Váradi, Tímea; Shrestha, Dilip; Baran, Irina; Katona, Eva; Nagy, Peter; Szöllosi, János

Mocanu, Maria-Magdalena; Ganea, Constanta; Georgescu, Laura; Váradi, Tímea; Shrestha, Dilip; Baran, Irina; Katona, Eva; Nagy, Peter; Szöllosi, János.

Affiliation

Mocanu MM; Department of Biophysics, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy , 050474 Bucharest, Romania.

J Nat Prod ; 77(2): 250-7, 2014 Feb 28.

Article in En | MEDLINE | ID: mdl-24456004

Subject(s)

Anticarcinogenic Agents/chemistry; Anticarcinogenic Agents/pharmacology; Catechin/analogs & derivatives; Flavonoids/pharmacology; Genistein/pharmacology; Receptors, Laminin/drug effects; Ribosomal Proteins/drug effects; Tea/chemistry; Algorithms; Anticarcinogenic Agents/isolation & purification; Apoptosis/drug effects; Carcinoma, Squamous Cell/metabolism; Catechin/chemistry; Catechin/isolation & purification; Catechin/pharmacology; Cell Proliferation/drug effects; Down-Regulation; ErbB Receptors/genetics; ErbB Receptors/metabolism; Female; Flavonoids/chemistry; Flavonoids/isolation & purification; G2 Phase Cell Cycle Checkpoints/genetics; G2 Phase Cell Cycle Checkpoints/physiology; Genes, erbB-1/genetics; Genes, erbB-1/physiology; Genes, erbB-2/genetics; Genes, erbB-2/physiology; Genistein/chemistry; Genistein/isolation & purification; Humans; Molecular Structure; Polyphenols/pharmacology; Receptors, Laminin/genetics; Receptors, Laminin/metabolism; Receptors, Laminin/physiology; Glycine max/chemistry

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Full text: 1 Database: MEDLINE Main subject: Ribosomal Proteins / Tea / Flavonoids / Catechin / Anticarcinogenic Agents / Receptors, Laminin / Genistein Limits: Female / Humans Language: En Journal: J Nat Prod Year: 2014 Type: Article Affiliation country: Romania

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