The ESCRT machinery: from the plasma membrane to endosomes and back again.
Crit Rev Biochem Mol Biol
; 49(3): 242-61, 2014.
Article
in En
| MEDLINE
| ID: mdl-24456136
ABSTRACT
The manipulation and reorganization of lipid bilayers are required for diverse cellular processes, ranging from organelle biogenesis to cytokinetic abscission, and often involves transient membrane disruption. A set of membrane-associated proteins collectively known as the endosomal sorting complex required for transport (ESCRT) machinery has been implicated in membrane scission steps, which transform a single, continuous bilayer into two distinct bilayers, while simultaneously segregating cargo throughout the process. Components of the ESCRT pathway, which include 5 distinct protein complexes and an array of accessory factors, each serve discrete functions. This review focuses on the molecular mechanisms by which the ESCRT proteins facilitate cargo sequestration and membrane remodeling and highlights their unique roles in cellular homeostasis.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Endosomes
/
Cell Membrane
/
Endosomal Sorting Complexes Required for Transport
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Crit Rev Biochem Mol Biol
Journal subject:
BIOLOGIA MOLECULAR
/
BIOQUIMICA
Year:
2014
Type:
Article
Affiliation country:
United States