IL-21 promotes CD4 T cell responses by phosphatidylinositol 3-kinase-dependent upregulation of CD86 on B cells.

Attridge, Kesley; Kenefeck, Rupert; Wardzinski, Lukasz; Qureshi, Omar S; Wang, Chun Jing; Manzotti, Claire; Okkenhaug, Klaus; Walker, Lucy S K

Attridge, Kesley; Kenefeck, Rupert; Wardzinski, Lukasz; Qureshi, Omar S; Wang, Chun Jing; Manzotti, Claire; Okkenhaug, Klaus; Walker, Lucy S K.

Affiliation

Attridge K; Medical Research Council Centre for Immune Regulation, University of Birmingham Medical School, Birmingham B15 2TT, United Kingdom;

J Immunol ; 192(5): 2195-201, 2014 Mar 01.

Article in En | MEDLINE | ID: mdl-24470500

Subject(s)

B-Lymphocytes/immunology; B7-2 Antigen/immunology; Interleukins/immunology; Phosphatidylinositol 3-Kinases/immunology; T-Lymphocytes, Regulatory/immunology; Up-Regulation/immunology; Animals; B-Lymphocytes/cytology; B-Lymphocytes/metabolism; B7-2 Antigen/biosynthesis; B7-2 Antigen/genetics; Interleukins/genetics; Interleukins/metabolism; Mice; Mice, Inbred BALB C; Mice, Knockout; Phosphatidylinositol 3-Kinases/genetics; Phosphatidylinositol 3-Kinases/metabolism; STAT3 Transcription Factor/genetics; STAT3 Transcription Factor/immunology; STAT3 Transcription Factor/metabolism; T-Lymphocytes, Regulatory/cytology; T-Lymphocytes, Regulatory/metabolism; Up-Regulation/genetics

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Full text: 1 Database: MEDLINE Main subject: B-Lymphocytes / Up-Regulation / Interleukins / T-Lymphocytes, Regulatory / Phosphatidylinositol 3-Kinases / B7-2 Antigen Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Immunol Year: 2014 Type: Article

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