Antioxidant drug therapy approaches for neuroprotection in chronic diseases of the retina.
Int J Mol Sci
; 15(2): 1865-86, 2014 Jan 27.
Article
in En
| MEDLINE
| ID: mdl-24473138
ABSTRACT
The molecular pathways contributing to visual signal transduction in the retina generate a high energy demand that has functional and structural consequences such as vascularization and high metabolic rates contributing to oxidative stress. Multiple signaling cascades are involved to actively regulate the redox state of the retina. Age-related processes increase the oxidative load, resulting in chronically elevated levels of oxidative stress and reactive oxygen species, which in the retina ultimately result in pathologies such as glaucoma or age-related macular degeneration, as well as the neuropathic complications of diabetes in the eye. Specifically, oxidative stress results in deleterious changes to the retina through dysregulation of its intracellular physiology, ultimately leading to neurodegenerative and potentially also vascular dysfunction. Herein we will review the evidence for oxidative stress-induced contributions to each of the three major ocular pathologies, glaucoma, age-related macular degeneration, and diabetic retinopathy. The premise for neuroprotective strategies for these ocular disorders will be discussed in the context of recent clinical and preclinical research pursuing novel therapy development approaches.
Full text:
1
Database:
MEDLINE
Main subject:
Retinal Diseases
/
Neuroprotective Agents
/
Antioxidants
Limits:
Animals
/
Humans
Language:
En
Journal:
Int J Mol Sci
Year:
2014
Type:
Article
Affiliation country:
United States