Engineering anisotropic biomimetic fibrocartilage microenvironment by bioprinting mesenchymal stem cells in nanoliter gel droplets.

Gurkan, Umut A; El Assal, Rami; Yildiz, Simin E; Sung, Yuree; Trachtenberg, Alexander J; Kuo, Winston P; Demirci, Utkan

Gurkan, Umut A; El Assal, Rami; Yildiz, Simin E; Sung, Yuree; Trachtenberg, Alexander J; Kuo, Winston P; Demirci, Utkan.

Affiliation

Gurkan UA; Case Biomanufacturing and Microfabrication Laboratory, Mechanical and Aerospace Engineering Department, Department of Orthopaedics, Case Western Reserve University , Cleveland, Ohio 44106, United States.

Mol Pharm ; 11(7): 2151-9, 2014 Jul 07.

Article in En | MEDLINE | ID: mdl-24495169

Subject(s)

Biomimetics/methods; Bioprinting/methods; Cellular Microenvironment/physiology; Fibrocartilage/physiology; Hydrogels/metabolism; Mesenchymal Stem Cells/physiology; Tissue Engineering/methods; Bone Morphogenetic Protein 2/metabolism; Cell Differentiation/genetics; Cell Differentiation/physiology; Cells, Cultured; Cellular Microenvironment/genetics; Chondrogenesis/genetics; Chondrogenesis/physiology; Fibrocartilage/metabolism; Gene Expression/genetics; Humans; Mesenchymal Stem Cells/metabolism; Osteogenesis/genetics; Osteogenesis/physiology; Signal Transduction/genetics; Transforming Growth Factor beta1/genetics; Transforming Growth Factor beta1/metabolism; Vascular Endothelial Growth Factor A/genetics; Vascular Endothelial Growth Factor A/metabolism

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Full text: 1 Database: MEDLINE Main subject: Hydrogels / Tissue Engineering / Biomimetics / Fibrocartilage / Mesenchymal Stem Cells / Cellular Microenvironment / Bioprinting Type of study: Prognostic_studies Limits: Humans Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2014 Type: Article Affiliation country: United States

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