Albumin-bound fatty acids but not albumin itself alter redox balance in tubular epithelial cells and induce a peroxide-mediated redox-sensitive apoptosis.

Ruggiero, Christine; Elks, Carrie M; Kruger, Claudia; Cleland, Ellen; Addison, Kaity; Noland, Robert C; Stadler, Krisztian

Ruggiero, Christine; Elks, Carrie M; Kruger, Claudia; Cleland, Ellen; Addison, Kaity; Noland, Robert C; Stadler, Krisztian.

Affiliation

Ruggiero C; Oxidative Stress and Disease Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808. krisztian.stadler@pbrc.edu.

Am J Physiol Renal Physiol ; 306(8): F896-906, 2014 Apr 15.

Article in En | MEDLINE | ID: mdl-24500687

Subject(s)

Albumins/metabolism; Apoptosis/drug effects; Fatty Acids/pharmacology; Albumins/pharmacology; Animals; Cell Survival/drug effects; Cells, Cultured; Epithelial Cells/pathology; Kidney Tubules, Proximal/cytology; Kidney Tubules, Proximal/metabolism; Membrane Potential, Mitochondrial/drug effects; Mitochondria/metabolism; Oxidation-Reduction; Palmitates/metabolism; Peroxiredoxins/metabolism; Rats; Serum Albumin, Bovine/pharmacology

Key words

albuminuria; apoptosis; lipotoxicity; peroxiredoxin; tubular cell

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Full text: 1 Database: MEDLINE Main subject: Apoptosis / Albumins / Fatty Acids Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Am J Physiol Renal Physiol Journal subject: FISIOLOGIA / NEFROLOGIA Year: 2014 Type: Article

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