Relationship of CYP3A5 genotype and ABCB1 diplotype to tacrolimus disposition in Brazilian kidney transplant patients.

Cusinato, Diego Alberto C; Lacchini, Riccardo; Romao, Elen A; Moysés-Neto, Miguel; Coelho, Eduardo B

Cusinato, Diego Alberto C; Lacchini, Riccardo; Romao, Elen A; Moysés-Neto, Miguel; Coelho, Eduardo B.

Affiliation

Cusinato DA; Department of Pharmacology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Av. Bandeirantes, 3900, 14049-900, Ribeirão Preto, São Paulo, Brazil.

Br J Clin Pharmacol ; 78(2): 364-72, 2014 Aug.

Article in En | MEDLINE | ID: mdl-24528196

Subject(s)

Calcineurin Inhibitors/pharmacokinetics; Cytochrome P-450 CYP3A/genetics; Graft Rejection/prevention & control; Kidney Transplantation; Tacrolimus/pharmacokinetics; ATP Binding Cassette Transporter, Subfamily B/genetics; Adult; Brazil; Calcineurin Inhibitors/administration & dosage; Calcineurin Inhibitors/therapeutic use; Female; Gene Frequency; Haplotypes; Homozygote; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Retrospective Studies; Tacrolimus/administration & dosage; Tacrolimus/therapeutic use; Tissue Distribution

Key words

ABCB1 diplotype; cytochrome P450; kidney transplantation; pharmacogenetics; tacrolimus pharmacokinetics

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Full text: 1 Database: MEDLINE Main subject: Kidney Transplantation / Tacrolimus / Cytochrome P-450 CYP3A / Calcineurin Inhibitors / Graft Rejection Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: America do sul / Brasil Language: En Journal: Br J Clin Pharmacol Year: 2014 Type: Article Affiliation country: Brazil

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