Site-specific antibody-drug conjugation through glycoengineering.

Zhou, Qun; Stefano, James E; Manning, Charlene; Kyazike, Josephine; Chen, Bo; Gianolio, Diego A; Park, Anna; Busch, Michelle; Bird, Julie; Zheng, Xiaoyang; Simonds-Mannes, Helene; Kim, Jennifer; Gregory, Rick C; Miller, Robert J; Brondyk, William H; Dhal, Pradeep K; Pan, Clark Q

Zhou, Qun; Stefano, James E; Manning, Charlene; Kyazike, Josephine; Chen, Bo; Gianolio, Diego A; Park, Anna; Busch, Michelle; Bird, Julie; Zheng, Xiaoyang; Simonds-Mannes, Helene; Kim, Jennifer; Gregory, Rick C; Miller, Robert J; Brondyk, William H; Dhal, Pradeep K; Pan, Clark Q.

Affiliation

Zhou Q; Sanofi-Genzyme R&D Center, Genzyme Corporation, A Sanofi Company , Framingham, Massachusetts 01701, United States.

Bioconjug Chem ; 25(3): 510-20, 2014 Mar 19.

Article in En | MEDLINE | ID: mdl-24533768

Subject(s)

Antibodies, Monoclonal, Humanized/pharmacology; Antibodies/chemistry; Antineoplastic Agents/pharmacology; Neoplasms, Experimental/drug therapy; Animals; Antibodies, Monoclonal, Humanized/chemistry; Antineoplastic Agents/chemistry; Cell Line, Tumor; Cell Proliferation/drug effects; Cell Survival/drug effects; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Glycosylation; Humans; Mice; Mice, SCID; Molecular Structure; Neoplasms, Experimental/pathology; Polysaccharides/chemistry; Sialic Acids/chemistry; Sialic Acids/metabolism; Sialyltransferases/chemistry; Sialyltransferases/metabolism; Structure-Activity Relationship; Trastuzumab

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Full text: 1 Database: MEDLINE Main subject: Antibodies, Monoclonal, Humanized / Antibodies / Neoplasms, Experimental / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Bioconjug Chem Journal subject: BIOQUIMICA Year: 2014 Type: Article Affiliation country: United States

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