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Preparation and optimization of new 4-(2-(indolin-1-yl)-2-oxoethyl)-2-morpholinothiazole-5-carboxylic acid and amide derivatives as potent and selective PI3Kß inhibitors.
Certal, Victor; Halley, Frank; Virone-Oddos, Angela; Filoche-Rommé, Bruno; Carry, Jean-Christophe; Gruss-Leleu, Florence; Bertin, Luc; Guizani, Houlfa; Pilorge, Fabienne; Richepin, Patrick; Karlsson, Andreas; Charrier, Véronique; Abecassis, Pierre-Yves; Vincent, Loic; Nicolas, Jean-Paul; Lengauer, Christoph; Garcia-Echeverria, Carlos; Schio, Laurent.
Affiliation
  • Certal V; Medicinal Chemistry Oncology Drug Discovery, Sanofi, 13, Quai Jules Guesde, 94400 Vitry-sur-Seine, France. Electronic address: victor.certal@sanofi.com.
  • Halley F; Medicinal Chemistry Oncology Drug Discovery, Sanofi, 13, Quai Jules Guesde, 94400 Vitry-sur-Seine, France.
  • Virone-Oddos A; Biology Oncology Drug Discovery, Sanofi, 13, Quai Jules Guesde, 94400 Vitry-sur-Seine, France.
  • Filoche-Rommé B; Medicinal Chemistry Oncology Drug Discovery, Sanofi, 13, Quai Jules Guesde, 94400 Vitry-sur-Seine, France.
  • Carry JC; Medicinal Chemistry Oncology Drug Discovery, Sanofi, 13, Quai Jules Guesde, 94400 Vitry-sur-Seine, France.
  • Gruss-Leleu F; Medicinal Chemistry Oncology Drug Discovery, Sanofi, 13, Quai Jules Guesde, 94400 Vitry-sur-Seine, France.
  • Bertin L; Medicinal Chemistry Oncology Drug Discovery, Sanofi, 13, Quai Jules Guesde, 94400 Vitry-sur-Seine, France.
  • Guizani H; Medicinal Chemistry Oncology Drug Discovery, Sanofi, 13, Quai Jules Guesde, 94400 Vitry-sur-Seine, France.
  • Pilorge F; Medicinal Chemistry Oncology Drug Discovery, Sanofi, 13, Quai Jules Guesde, 94400 Vitry-sur-Seine, France.
  • Richepin P; Medicinal Chemistry Oncology Drug Discovery, Sanofi, 13, Quai Jules Guesde, 94400 Vitry-sur-Seine, France.
  • Karlsson A; Structural Biology and Molecular Modeling, Sanofi, 13, Quai Jules Guesde, 94400 Vitry-sur-Seine, France.
  • Charrier V; Biology Oncology Drug Discovery, Sanofi, 13, Quai Jules Guesde, 94400 Vitry-sur-Seine, France.
  • Abecassis PY; Drug Safety, Sanofi, 13, Quai Jules Guesde, 94400 Vitry-sur-Seine, France.
  • Vincent L; Biology Oncology Drug Discovery, Sanofi, 13, Quai Jules Guesde, 94400 Vitry-sur-Seine, France.
  • Nicolas JP; Biology Oncology Drug Discovery, Sanofi, 13, Quai Jules Guesde, 94400 Vitry-sur-Seine, France.
  • Lengauer C; Biology Oncology Drug Discovery, Sanofi, 13, Quai Jules Guesde, 94400 Vitry-sur-Seine, France.
  • Garcia-Echeverria C; Medicinal Chemistry Oncology Drug Discovery, Sanofi, 13, Quai Jules Guesde, 94400 Vitry-sur-Seine, France.
  • Schio L; Medicinal Chemistry Oncology Drug Discovery, Sanofi, 13, Quai Jules Guesde, 94400 Vitry-sur-Seine, France.
Bioorg Med Chem Lett ; 24(6): 1506-10, 2014 Mar 15.
Article in En | MEDLINE | ID: mdl-24560540
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Full text: 1 Database: MEDLINE Main subject: Carboxylic Acids / Protein Kinase Inhibitors / Amides / Phosphoinositide-3 Kinase Inhibitors / Indoles Limits: Animals / Humans / Male Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2014 Type: Article
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Carboxylic Acids / Protein Kinase Inhibitors / Amides / Phosphoinositide-3 Kinase Inhibitors / Indoles Limits: Animals / Humans / Male Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2014 Type: Article