Down-regulation of serum gonadotropins but not estrogen replacement improves cognition in aged-ovariectomized 3xTg AD female mice.

Palm, Russell; Chang, Jaewon; Blair, Jeffrey; Garcia-Mesa, Yoelvis; Lee, Hyoung-Gon; Castellani, Rudy J; Smith, Mark A; Zhu, Xiongwei; Casadesus, Gemma

Palm, Russell; Chang, Jaewon; Blair, Jeffrey; Garcia-Mesa, Yoelvis; Lee, Hyoung-Gon; Castellani, Rudy J; Smith, Mark A; Zhu, Xiongwei; Casadesus, Gemma.

Affiliation

Palm R; Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio, USA.

J Neurochem ; 130(1): 115-25, 2014 Jul.

Article in En | MEDLINE | ID: mdl-24601954

Subject(s)

Aging/blood; Cognition/physiology; Down-Regulation/physiology; Estrogen Replacement Therapy/methods; Estrogens/administration & dosage; Luteinizing Hormone/blood; Ovariectomy; Animals; Biomarkers/blood; Cells, Cultured; Female; Gonadotropins/blood; Hippocampus/metabolism; Mice; Mice, Transgenic; Rats; Rats, Sprague-Dawley

Key words

3xTg AD; Alzheimer's disease; GSK3ß; estrogen; luteinizing hormone; ovariectomy

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Full text: 1 Database: MEDLINE Main subject: Aging / Luteinizing Hormone / Ovariectomy / Down-Regulation / Estrogen Replacement Therapy / Cognition / Estrogens Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Neurochem Year: 2014 Type: Article Affiliation country: United States

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