Hyperinsulinemia potentiates airway responsiveness to parasympathetic nerve stimulation in obese rats.

Nie, Zhenying; Jacoby, David B; Fryer, Allison D

Nie, Zhenying; Jacoby, David B; Fryer, Allison D.

Affiliation

Nie Z; Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon.

Am J Respir Cell Mol Biol ; 51(2): 251-61, 2014 Aug.

Article in En | MEDLINE | ID: mdl-24605871

Subject(s)

Asthma/etiology; Bronchial Hyperreactivity/etiology; Bronchoconstriction; Hyperinsulinism/complications; Lung/innervation; Obesity/complications; Vagus Nerve/physiopathology; Acetylcholine/metabolism; Acetylcholine/pharmacology; Animals; Asthma/metabolism; Asthma/physiopathology; Bronchial Hyperreactivity/metabolism; Bronchial Hyperreactivity/physiopathology; Bronchial Hyperreactivity/prevention & control; Bronchoconstriction/drug effects; Bronchoconstrictor Agents/pharmacology; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Humans; Hyperinsulinism/metabolism; Hyperinsulinism/physiopathology; Hypoglycemic Agents/pharmacology; Insulin/metabolism; Insulin/pharmacology; Muscarinic Agonists/pharmacology; Neural Inhibition; Obesity/metabolism; Obesity/physiopathology; Rats; Receptor, Muscarinic M2/metabolism; Receptor, Muscarinic M3/metabolism; Streptozocin/pharmacology; Time Factors; Vagus Nerve/drug effects; Vagus Nerve/metabolism

Key words

airway responsiveness; asthma; hyperinsulinemia; neural M2 muscarinic receptor; obesity

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Full text: 1 Database: MEDLINE Main subject: Asthma / Vagus Nerve / Bronchoconstriction / Bronchial Hyperreactivity / Hyperinsulinism / Lung / Obesity Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Am J Respir Cell Mol Biol Journal subject: BIOLOGIA MOLECULAR Year: 2014 Type: Article

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