A copper chelate selectively triggers apoptosis in myeloid-derived suppressor cells in a drug-resistant tumor model and enhances antitumor immune response.

Chakraborty, Paramita; Das, Satyajit; Banerjee, Kaushik; Sinha, Abhinaba; Roy, Susmita; Chatterjee, Mitali; Choudhuri, Soumitra Kumar

Chakraborty, Paramita; Das, Satyajit; Banerjee, Kaushik; Sinha, Abhinaba; Roy, Susmita; Chatterjee, Mitali; Choudhuri, Soumitra Kumar.

Affiliation

Chakraborty P; Department of In Vitro Carcinogenesis and Cellular Chemotherapy, Chittaranjan National Cancer Institute , Kolkata, West Bengal , India and.

Immunopharmacol Immunotoxicol ; 36(2): 165-75, 2014 Apr.

Article in En | MEDLINE | ID: mdl-24611750

Subject(s)

Antineoplastic Agents/immunology; Apoptosis/drug effects; Apoptosis/immunology; Chelating Agents/pharmacology; Copper/immunology; Copper/pharmacology; Myeloid Cells/immunology; Animals; Bone Marrow Cells/drug effects; Bone Marrow Cells/metabolism; CD4-Positive T-Lymphocytes/drug effects; CD4-Positive T-Lymphocytes/immunology; Cell Line, Tumor; Doxorubicin/pharmacology; Lymphocyte Activation/drug effects; Lymphocyte Activation/immunology; Mice; Myeloid Cells/drug effects; T-Lymphocytes, Regulatory/drug effects; T-Lymphocytes, Regulatory/immunology; Th1 Cells/drug effects; Th1 Cells/immunology; fas Receptor/immunology

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Full text: 1 Database: MEDLINE Main subject: Chelating Agents / Apoptosis / Copper / Myeloid Cells / Antineoplastic Agents Type of study: Guideline / Prognostic_studies Limits: Animals Language: En Journal: Immunopharmacol Immunotoxicol Journal subject: ALERGIA E IMUNOLOGIA / FARMACOLOGIA / TOXICOLOGIA Year: 2014 Type: Article

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