Mapping of the binding landscape for a picomolar protein-protein complex through computation and experiment.

Aizner, Yonatan; Sharabi, Oz; Shirian, Jason; Dakwar, George R; Risman, Marina; Avraham, Orly; Shifman, Julia

Aizner, Yonatan; Sharabi, Oz; Shirian, Jason; Dakwar, George R; Risman, Marina; Avraham, Orly; Shifman, Julia.

Affiliation

Aizner Y; Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Sharabi O; Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Shirian J; Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Dakwar GR; Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Risman M; Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Avraham O; Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Shifman J; Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. Electronic address: jshifman@cc.huji.ac.il.

Structure ; 22(4): 636-45, 2014 Apr 08.

Article in En | MEDLINE | ID: mdl-24613488

Subject(s)

Acetylcholinesterase/chemistry; Cholinesterase Inhibitors/chemistry; Elapid Venoms/chemistry; Peptide Mapping/statistics & numerical data; Acetylcholinesterase/genetics; Amino Acid Sequence; Animals; Binding Sites; Escherichia coli/genetics; Escherichia coli/metabolism; Gene Expression; Humans; Kinetics; Models, Molecular; Molecular Sequence Data; Mutation; Protein Binding; Recombinant Proteins/chemistry; Recombinant Proteins/genetics; Thermodynamics; Torpedo

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Acetylcholinesterase / Peptide Mapping / Cholinesterase Inhibitors / Elapid Venoms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Structure Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA / BIOTECNOLOGIA Year: 2014 Type: Article Affiliation country: Israel

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google