Pertussis pathogenesis--what we know and what we don't know.
J Infect Dis
; 209(7): 982-5, 2014 Apr 01.
Article
in En
| MEDLINE
| ID: mdl-24626533
ABSTRACT
Pertussis is a worldwide public health threat. Bordetella pertussis produces multiple virulence factors that have been studied individually, and many have recently been found to have additional biological activities. Nevertheless, how they interact to cause the disease pertussis remains unknown. New animal models, particularly the infection of infant baboons with B. pertussis, are enabling longstanding questions about pertussis pathogenesis to be answered and new ones to be asked. Enhancing our understanding of pathogenesis will enable new approaches to the prevention and control of pertussis.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Bacterial Proteins
/
Bordetella pertussis
/
Whooping Cough
/
Virulence Factors
Type of study:
Etiology_studies
/
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
J Infect Dis
Year:
2014
Type:
Article