Pau d'arco activates Nrf2-dependent gene expression via the MEK/ERK-pathway.

Richter, Michelle; Winkel, Angelika F; Schummer, Dietmar; Gerlitz, Martin; de Hoop, Meltsje; Brunner, Bodo; Glien, Maike; Schmoll, Dieter

Richter, Michelle; Winkel, Angelika F; Schummer, Dietmar; Gerlitz, Martin; de Hoop, Meltsje; Brunner, Bodo; Glien, Maike; Schmoll, Dieter.

Affiliation

Richter M; Sanofi-Aventis Deutschland, R&D, Industriepark Hoechst, Germany.

J Toxicol Sci ; 39(2): 353-61, 2014 Apr.

Article in En | MEDLINE | ID: mdl-24646717

Subject(s)

Gene Expression/drug effects; MAP Kinase Signaling System/drug effects; Medicine, Traditional; Molecular Targeted Therapy; NF-E2-Related Factor 2/metabolism; NF-E2-Related Factor 2/physiology; Phytotherapy; Plant Extracts/pharmacology; Tabebuia; Active Transport, Cell Nucleus; Animals; Female; Heme Oxygenase-1/metabolism; Hep G2 Cells; Humans; Intestines; Intracellular Signaling Peptides and Proteins/physiology; Kelch-Like ECH-Associated Protein 1; MAP Kinase Signaling System/genetics; MAP Kinase Signaling System/physiology; Mice; Mice, Inbred C57BL; NAD(P)H Dehydrogenase (Quinone)/metabolism; NF-E2-Related Factor 2/genetics; Stimulation, Chemical; Water

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Database: MEDLINE Main subject: Plant Extracts / Gene Expression / MAP Kinase Signaling System / Tabebuia / NF-E2-Related Factor 2 / Molecular Targeted Therapy / Phytotherapy / Medicine, Traditional Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: J Toxicol Sci Year: 2014 Type: Article Affiliation country: Germany

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