Both bone marrow-derived and non-bone marrow-derived cells contribute to AIM2 and NLRP3 inflammasome activation in a MyD88-dependent manner in dietary steatohepatitis.

Csak, Timea; Pillai, Arun; Ganz, Michal; Lippai, Dora; Petrasek, Jan; Park, Jin-Kyu; Kodys, Karen; Dolganiuc, Angela; Kurt-Jones, Evelyn A; Szabo, Gyongyi

Csak, Timea; Pillai, Arun; Ganz, Michal; Lippai, Dora; Petrasek, Jan; Park, Jin-Kyu; Kodys, Karen; Dolganiuc, Angela; Kurt-Jones, Evelyn A; Szabo, Gyongyi.

Affiliation

Csak T; Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.

Liver Int ; 34(9): 1402-13, 2014 Oct.

Article in En | MEDLINE | ID: mdl-24650018

Subject(s)

Carrier Proteins/metabolism; DNA-Binding Proteins/metabolism; Gene Expression Regulation/physiology; Inflammasomes/metabolism; Myeloid Differentiation Factor 88/metabolism; Non-alcoholic Fatty Liver Disease/metabolism; Signal Transduction/physiology; Animals; Blotting, Western; Bone Marrow Cells/metabolism; Choline Deficiency; Diet; Immunoprecipitation; Methionine/deficiency; Mice; Mice, Knockout; Myeloid Differentiation Factor 88/genetics; NLR Family, Pyrin Domain-Containing 3 Protein; Real-Time Polymerase Chain Reaction; Statistics, Nonparametric; Toll-Like Receptor 4/genetics; Toll-Like Receptor 4/metabolism; Toll-Like Receptor 9/metabolism

Key words

AIM2; HMGB1; IL-1ß; MyD88; NLRP3; TLR4; TLR9; caspase-1; inflammasome; non-alcoholic steatohepatitis

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Full text: 1 Database: MEDLINE Main subject: Signal Transduction / Carrier Proteins / Gene Expression Regulation / DNA-Binding Proteins / Myeloid Differentiation Factor 88 / Inflammasomes / Non-alcoholic Fatty Liver Disease Limits: Animals Language: En Journal: Liver Int Journal subject: GASTROENTEROLOGIA Year: 2014 Type: Article Affiliation country: United States

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