Losartan prevents acquired epilepsy via TGF-ß signaling suppression.

Bar-Klein, Guy; Cacheaux, Luisa P; Kamintsky, Lyn; Prager, Ofer; Weissberg, Itai; Schoknecht, Karl; Cheng, Paul; Kim, Soo Young; Wood, Lydia; Heinemann, Uwe; Kaufer, Daniela; Friedman, Alon

Bar-Klein, Guy; Cacheaux, Luisa P; Kamintsky, Lyn; Prager, Ofer; Weissberg, Itai; Schoknecht, Karl; Cheng, Paul; Kim, Soo Young; Wood, Lydia; Heinemann, Uwe; Kaufer, Daniela; Friedman, Alon.

Affiliation

Bar-Klein G; Departments of Physiology and Cell Biology, Cognitive and Brain Sciences, Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Ann Neurol ; 75(6): 864-75, 2014 Jun.

Article in En | MEDLINE | ID: mdl-24659129

Subject(s)

Anticonvulsants/therapeutic use; Epilepsy/prevention & control; Losartan/therapeutic use; Signal Transduction/drug effects; Transforming Growth Factor beta/metabolism; Animals; Animals, Newborn; Anticonvulsants/pharmacology; Astrocytes/drug effects; Astrocytes/metabolism; Benzamides/pharmacology; Blood-Brain Barrier/physiology; Cells, Cultured; Cerebral Cortex/cytology; Dioxoles/pharmacology; Disease Models, Animal; Embryo, Mammalian; Endocytosis/drug effects; Epilepsy/chemically induced; Epilepsy/pathology; Epilepsy/physiopathology; Male; Neurons/drug effects; Neurons/metabolism; Phosphopyruvate Hydratase/metabolism; Rats; Rats, Wistar; Signal Transduction/physiology; Transforming Growth Factor beta/antagonists & inhibitors; Transforming Growth Factor beta/genetics

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Signal Transduction / Transforming Growth Factor beta / Losartan / Epilepsy / Anticonvulsants Type of study: Prognostic_studies Limits: Animals Language: En Journal: Ann Neurol Year: 2014 Type: Article Affiliation country: Israel

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google