Sweat chloride as a biomarker of CFTR activity: proof of concept and ivacaftor clinical trial data.

Accurso, Frank J; Van Goor, Fredrick; Zha, Jiuhong; Stone, Anne J; Dong, Qunming; Ordonez, Claudia L; Rowe, Steven M; Clancy, John Paul; Konstan, Michael W; Hoch, Heather E; Heltshe, Sonya L; Ramsey, Bonnie W; Campbell, Preston W; Ashlock, Melissa A

Accurso, Frank J; Van Goor, Fredrick; Zha, Jiuhong; Stone, Anne J; Dong, Qunming; Ordonez, Claudia L; Rowe, Steven M; Clancy, John Paul; Konstan, Michael W; Hoch, Heather E; Heltshe, Sonya L; Ramsey, Bonnie W; Campbell, Preston W; Ashlock, Melissa A.

J Cyst Fibros ; 13(2): 139-47, 2014 Mar.

Article in En | MEDLINE | ID: mdl-24660233

Subject(s)

Aminophenols/pharmacology; Chlorides; Cystic Fibrosis Transmembrane Conductance Regulator; Nasal Mucosa; Quinolones/pharmacology; Sweat; Adult; Biomarkers; Child; Chlorides/analysis; Chlorides/metabolism; Cystic Fibrosis/drug therapy; Cystic Fibrosis/genetics; Cystic Fibrosis/metabolism; Cystic Fibrosis Transmembrane Conductance Regulator/genetics; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism; Dose-Response Relationship, Drug; Double-Blind Method; Drug Monitoring/methods; Female; Humans; Male; Mutation; Nasal Mucosa/metabolism; Nasal Mucosa/physiopathology; Reproducibility of Results; Respiratory System Agents/pharmacology; Specimen Handling/methods; Specimen Handling/standards; Sweat/chemistry; Sweat/metabolism; Treatment Outcome

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Sweat / Chlorides / Quinolones / Cystic Fibrosis Transmembrane Conductance Regulator / Aminophenols / Nasal Mucosa Type of study: Clinical_trials / Prognostic_studies Limits: Adult / Child / Female / Humans / Male Language: En Journal: J Cyst Fibros Year: 2014 Type: Article

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google