GABAergic transmission in rat pontine reticular formation regulates the induction phase of anesthesia and modulates hyperalgesia caused by sleep deprivation.

Vanini, Giancarlo; Nemanis, Kriste; Baghdoyan, Helen A; Lydic, Ralph

Vanini, Giancarlo; Nemanis, Kriste; Baghdoyan, Helen A; Lydic, Ralph.

Affiliation

Vanini G; Department of Anesthesiology, University of Michigan, 7433 Medical Science Building I, 1150 West Medical Center Drive, Ann Arbor, MI, 48109-5615, USA.

Eur J Neurosci ; 40(1): 2264-73, 2014 Jul.

Article in En | MEDLINE | ID: mdl-24674578

Subject(s)

Anesthetics, General/pharmacology; Pontine Tegmentum/drug effects; Pontine Tegmentum/physiopathology; Sleep Deprivation/physiopathology; gamma-Aminobutyric Acid/metabolism; 3-Mercaptopropionic Acid/pharmacology; Animals; Consciousness/drug effects; Consciousness/physiology; GABA Agents/pharmacology; GABA Uptake Inhibitors/pharmacology; Hot Temperature; Hyperalgesia/physiopathology; Isoflurane/pharmacology; Male; Nipecotic Acids/pharmacology; Nociception/drug effects; Nociception/physiology; Pain Threshold/drug effects; Pain Threshold/physiology; Propofol/pharmacology; Rats, Sprague-Dawley; Reflex, Righting/drug effects; Reflex, Righting/physiology; Time Factors

Key words

consciousness; emergence; microdialysis; microinjection; pain

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Full text: 1 Database: MEDLINE Main subject: Sleep Deprivation / Anesthetics, General / Pontine Tegmentum / Gamma-Aminobutyric Acid Limits: Animals Language: En Journal: Eur J Neurosci Journal subject: NEUROLOGIA Year: 2014 Type: Article Affiliation country: United States

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