Functional inhibition of aquaporin-3 with a gold-based compound induces blockage of cell proliferation.

Serna, Ana; Galán-Cobo, Ana; Rodrigues, Claudia; Sánchez-Gomar, Ismael; Toledo-Aral, Juan José; Moura, Teresa F; Casini, Angela; Soveral, Graça; Echevarría, Miriam

Serna, Ana; Galán-Cobo, Ana; Rodrigues, Claudia; Sánchez-Gomar, Ismael; Toledo-Aral, Juan José; Moura, Teresa F; Casini, Angela; Soveral, Graça; Echevarría, Miriam.

Affiliation

Serna A; Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla (Departamento de Fisiología Médica y Biofísica), Seville, Spain.

J Cell Physiol ; 229(11): 1787-801, 2014 Nov.

Article in En | MEDLINE | ID: mdl-24676973

Subject(s)

Aquaporin 3/antagonists & inhibitors; Coordination Complexes/pharmacology; Gold/pharmacology; Animals; Aquaporin 3/genetics; Aquaporin 3/metabolism; Bromodeoxyuridine/metabolism; Cell Count; Cell Cycle/drug effects; Cell Death/drug effects; Cell Membrane/drug effects; Cell Membrane/metabolism; Cell Membrane Permeability/drug effects; Cell Proliferation/drug effects; Cell Survival/drug effects; Coordination Complexes/chemistry; Flow Cytometry; Gene Expression Regulation/drug effects; Glycerol/metabolism; Gold/toxicity; HEK293 Cells; Humans; Mice; Mutagenesis, Site-Directed; NIH 3T3 Cells; PC12 Cells; RNA, Messenger/genetics; RNA, Messenger/metabolism; Rats; Water/metabolism

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Full text: 1 Database: MEDLINE Main subject: Aquaporin 3 / Coordination Complexes / Gold Limits: Animals / Humans Language: En Journal: J Cell Physiol Year: 2014 Type: Article Affiliation country: Spain

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