PI3K signalling in GnRH actions on dispersed goldfish pituitary cells: relationship with PKC-mediated LH and GH release and regulation of long-term effects on secretion and total cellular hormone availability.

Pemberton, Joshua G; Orr, Michael E; Stafford, James L; Chang, John P

Pemberton, Joshua G; Orr, Michael E; Stafford, James L; Chang, John P.

Affiliation

Pemberton JG; Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada.
Orr ME; Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada.
Stafford JL; Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada.
Chang JP; Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada. Electronic address: john.chang@ualberta.ca.

Gen Comp Endocrinol ; 205: 268-78, 2014 Sep 01.

Article in En | MEDLINE | ID: mdl-24681225

Subject(s)

Goldfish/metabolism; Growth Hormone/metabolism; Luteinizing Hormone/metabolism; Phosphatidylinositol 3-Kinases/metabolism; Pituitary Gland/cytology; Protein Kinase C/metabolism; Signal Transduction; Animals; Chromones/pharmacology; Enzyme Activators/pharmacology; Gonadotropin-Releasing Hormone/metabolism; Morpholines/pharmacology; Phosphorylation/drug effects; Pituitary Gland/drug effects; Pituitary Gland/metabolism; Proto-Oncogene Proteins c-akt/metabolism; Signal Transduction/drug effects; Time Factors

Key words

Endogenous GnRH forms; PI3K and PKC signalling; PI3K inhibitor LY294002; Perifusion and static incubation; Primary cultures of dispersed goldfish pituitary cells

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Full text: 1 Database: MEDLINE Main subject: Pituitary Gland / Protein Kinase C / Goldfish / Growth Hormone / Luteinizing Hormone / Signal Transduction / Phosphatidylinositol 3-Kinases Limits: Animals Language: En Journal: Gen Comp Endocrinol Year: 2014 Type: Article Affiliation country: Canada

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