Antiproliferative effects of 12-oxoheteronemin vs heteronemin.
Nat Prod Commun
; 9(3): 359-60, 2014 Mar.
Article
in En
| MEDLINE
| ID: mdl-24689214
ABSTRACT
The antiproliferative activities of 12-oxoheteronemin and heteronemin were evaluated in six cancer cell lines and IC50 values ranging from 0.66 to 1.35 microM were obtained. In four of the cell lines, 12-oxoheteronemin and heteronemin were equipotent; however, in two estrogenic receptor-positive cell lines, heteronemin showed a stronger potency. Both compounds had no overt effects on cell cycle distribution in HeLa cells, but did rapidly initiate apoptosis as evidenced by increased sub-G1 populations of cells and caspase-dependent PARP cleavage.
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Database:
MEDLINE
Main subject:
Terpenes
/
Apoptosis
/
Cell Proliferation
Limits:
Humans
Language:
En
Journal:
Nat Prod Commun
Journal subject:
BOTANICA
/
FARMACOLOGIA
/
QUIMICA
Year:
2014
Type:
Article