Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor ß/Î´ (FABP5-PPARß/Î´) signaling pathway.

Armstrong, Eric H; Goswami, Devrishi; Griffin, Patrick R; Noy, Noa; Ortlund, Eric A

Armstrong, Eric H; Goswami, Devrishi; Griffin, Patrick R; Noy, Noa; Ortlund, Eric A.

Affiliation

Armstrong EH; From the Department of Biochemistry, Discovery and Developmental Therapeutics, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322.
Goswami D; the Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida 33458, and.
Griffin PR; the Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida 33458, and.
Noy N; the Departments of Pharmacology and Nutrition, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106.
Ortlund EA; From the Department of Biochemistry, Discovery and Developmental Therapeutics, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, eortlun@emory.edu.

J Biol Chem ; 289(21): 14941-54, 2014 May 23.

Article in En | MEDLINE | ID: mdl-24692551

Subject(s)

Fatty Acid-Binding Proteins/metabolism; Fatty Acids/metabolism; PPAR gamma/metabolism; PPAR-beta/metabolism; Animals; Arachidonic Acid/chemistry; Arachidonic Acid/metabolism; Arachidonic Acid/pharmacology; Binding Sites; COS Cells; Cell Nucleus/drug effects; Cell Nucleus/metabolism; Chlorocebus aethiops; Cytoplasm/drug effects; Cytoplasm/metabolism; Fatty Acid-Binding Proteins/chemistry; Fatty Acid-Binding Proteins/genetics; Fatty Acids/chemistry; Fatty Acids/pharmacology; Humans; Ligands; Linoleic Acid/chemistry; Linoleic Acid/metabolism; Linoleic Acid/pharmacology; MCF-7 Cells; Models, Molecular; Molecular Structure; Mutation; Nuclear Localization Signals/chemistry; Nuclear Localization Signals/metabolism; PPAR gamma/genetics; PPAR-beta/genetics; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Transport/drug effects; Transcriptional Activation/drug effects

Key words

Fatty Acid; Fatty Acid-binding Protein; Lipids; Nuclear Receptors; Polyunsaturated Fatty Acids; Structural Biology

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Full text: 1 Database: MEDLINE Main subject: PPAR-beta / PPAR gamma / Fatty Acid-Binding Proteins / Fatty Acids Language: En Journal: J Biol Chem Year: 2014 Type: Article

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Full text: 1 Database: MEDLINE Main subject: PPAR-beta / PPAR gamma / Fatty Acid-Binding Proteins / Fatty Acids Language: En Journal: J Biol Chem Year: 2014 Type: Article