Characteristics of the cation cotransporter NKCC1 in human brain: alternate transcripts, expression in development, and potential relationships to brain function and schizophrenia.

Morita, Yukitaka; Callicott, Joseph H; Testa, Lauren R; Mighdoll, Michelle I; Dickinson, Dwight; Chen, Qiang; Tao, Ran; Lipska, Barbara K; Kolachana, Bhaskar; Law, Amanda J; Ye, Tianzhang; Straub, Richard E; Weinberger, Daniel R; Kleinman, Joel E; Hyde, Thomas M

Morita, Yukitaka; Callicott, Joseph H; Testa, Lauren R; Mighdoll, Michelle I; Dickinson, Dwight; Chen, Qiang; Tao, Ran; Lipska, Barbara K; Kolachana, Bhaskar; Law, Amanda J; Ye, Tianzhang; Straub, Richard E; Weinberger, Daniel R; Kleinman, Joel E; Hyde, Thomas M.

Affiliation

Morita Y; Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, Department of Psychiatry, Hiroshima City Hospital, Hiroshima City, Hiroshima Prefecture, 730-8518, Japan, Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, Maryland 21205, Neurodevelopmental and Neuropsychiatric Genetics Laboratory, Departments of Psychiatry

J Neurosci ; 34(14): 4929-40, 2014 Apr 02.

Article in En | MEDLINE | ID: mdl-24695712

Subject(s)

Gene Expression Regulation, Developmental/physiology; Prefrontal Cortex/metabolism; Schizophrenia/pathology; Solute Carrier Family 12, Member 2/metabolism; Adolescent; Adult; Aged; Child; Child, Preschool; Cognition Disorders/diagnosis; Cognition Disorders/etiology; Cohort Studies; DNA, Recombinant; Female; Fetus; Genotype; HEK293 Cells; Humans; Infant; Infant, Newborn; Male; Middle Aged; Mutation/genetics; Oxygen/blood; Postmortem Changes; Prefrontal Cortex/blood supply; Prefrontal Cortex/embryology; Prefrontal Cortex/growth & development; Psychiatric Status Rating Scales; Solute Carrier Family 12, Member 2/genetics; Young Adult

Key words

GABA; NKCC1; mRNA; neurotransmitter; schizophrenia; transcripts

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Full text: 1 Database: MEDLINE Main subject: Schizophrenia / Prefrontal Cortex / Gene Expression Regulation, Developmental / Solute Carrier Family 12, Member 2 Type of study: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Language: En Journal: J Neurosci Year: 2014 Type: Article

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