Lack of significant elevation of myeloid-derived suppressor cells in peripheral blood of chronically hepatitis C virus-infected individuals.
J Virol
; 88(13): 7678-82, 2014 Jul.
Article
in En
| MEDLINE
| ID: mdl-24741087
ABSTRACT
Myeloid-derived suppressor cells (MDSC) are immature myeloid cells with immunosuppressive function. Compared to the level in healthy controls (HC), no elevation of MDSC in chronic hepatitis C (cHEP-C) patients was found, and there was no difference in MDSC based on genotype or viral load (P > 0.25). Moreover, MDSC of cHEP-C patients inhibited CD8 T cell function as efficiently as MDSC of HC did. Since we detected neither quantitative nor qualitative differences in MDSC of cHEP-C patients relative to those of HC, we postulate that MDSC in peripheral blood are most likely not significant regarding immune dysfunction in cHEP-C.
Full text:
1
Database:
MEDLINE
Main subject:
Lymphocyte Activation
/
Hepacivirus
/
CD8-Positive T-Lymphocytes
/
Viral Load
/
Hepatitis C, Chronic
/
Myeloid Cells
Type of study:
Observational_studies
/
Qualitative_research
Limits:
Female
/
Humans
/
Male
Language:
En
Journal:
J Virol
Year:
2014
Type:
Article
Affiliation country:
Germany