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Uterine leiomyoma-linked MED12 mutations disrupt mediator-associated CDK activity.
Turunen, Mikko; Spaeth, Jason M; Keskitalo, Salla; Park, Min Ju; Kivioja, Teemu; Clark, Alison D; Mäkinen, Netta; Gao, Fangjian; Palin, Kimmo; Nurkkala, Helka; Vähärautio, Anna; Aavikko, Mervi; Kämpjärvi, Kati; Vahteristo, Pia; Kim, Chongwoo A; Aaltonen, Lauri A; Varjosalo, Markku; Taipale, Jussi; Boyer, Thomas G.
Affiliation
  • Turunen M; Genome-Scale Biology Program and Department of Pathology, Haartman Institute, University of Helsinki, Biomedicum, P.O. Box 63 (Haartmaninkatu 8), Helsinki FIN-00014, Finland.
  • Spaeth JM; Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Code 8257, STRF, San Antonio, TX 78229-3900, USA.
  • Keskitalo S; Institute of Biotechnology, University of Helsinki, Viikinkaari 1, P.O. Box 65, Helsinki FIN-00014, Finland.
  • Park MJ; Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Code 8257, STRF, San Antonio, TX 78229-3900, USA.
  • Kivioja T; Genome-Scale Biology Program and Department of Pathology, Haartman Institute, University of Helsinki, Biomedicum, P.O. Box 63 (Haartmaninkatu 8), Helsinki FIN-00014, Finland; Department of Computer Science, University of Helsinki, P.O. Box 68, Helsinki FIN-00014, Finland.
  • Clark AD; Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Code 8257, STRF, San Antonio, TX 78229-3900, USA.
  • Mäkinen N; Genome-Scale Biology Program and Department of Medical Genetics, Haartman Institute, University of Helsinki, Biomedicum, P.O. Box 63 (Haartmaninkatu 8), Helsinki FIN-00014, Finland.
  • Gao F; Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Code 8257, STRF, San Antonio, TX 78229-3900, USA.
  • Palin K; Genome-Scale Biology Program and Department of Pathology, Haartman Institute, University of Helsinki, Biomedicum, P.O. Box 63 (Haartmaninkatu 8), Helsinki FIN-00014, Finland.
  • Nurkkala H; Institute of Biotechnology, University of Helsinki, Viikinkaari 1, P.O. Box 65, Helsinki FIN-00014, Finland.
  • Vähärautio A; Genome-Scale Biology Program and Department of Pathology, Haartman Institute, University of Helsinki, Biomedicum, P.O. Box 63 (Haartmaninkatu 8), Helsinki FIN-00014, Finland; Science for Life Laboratory, Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm 14183, Sweden.
  • Aavikko M; Genome-Scale Biology Program and Department of Medical Genetics, Haartman Institute, University of Helsinki, Biomedicum, P.O. Box 63 (Haartmaninkatu 8), Helsinki FIN-00014, Finland.
  • Kämpjärvi K; Genome-Scale Biology Program and Department of Medical Genetics, Haartman Institute, University of Helsinki, Biomedicum, P.O. Box 63 (Haartmaninkatu 8), Helsinki FIN-00014, Finland.
  • Vahteristo P; Genome-Scale Biology Program and Department of Medical Genetics, Haartman Institute, University of Helsinki, Biomedicum, P.O. Box 63 (Haartmaninkatu 8), Helsinki FIN-00014, Finland.
  • Kim CA; Department of Biochemistry, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA.
  • Aaltonen LA; Genome-Scale Biology Program and Department of Medical Genetics, Haartman Institute, University of Helsinki, Biomedicum, P.O. Box 63 (Haartmaninkatu 8), Helsinki FIN-00014, Finland.
  • Varjosalo M; Institute of Biotechnology, University of Helsinki, Viikinkaari 1, P.O. Box 65, Helsinki FIN-00014, Finland. Electronic address: markku.varjosalo@helsinki.fi.
  • Taipale J; Genome-Scale Biology Program and Department of Pathology, Haartman Institute, University of Helsinki, Biomedicum, P.O. Box 63 (Haartmaninkatu 8), Helsinki FIN-00014, Finland; Science for Life Laboratory, Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm 14183, Sweden. Electro
  • Boyer TG; Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Code 8257, STRF, San Antonio, TX 78229-3900, USA. Electronic address: boyer@uthscsa.edu.
Cell Rep ; 7(3): 654-60, 2014 May 08.
Article in En | MEDLINE | ID: mdl-24746821
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Full text: 1 Database: MEDLINE Main subject: Uterine Neoplasms / Cyclin-Dependent Kinases / Mediator Complex / Cyclin-Dependent Kinase 8 / Leiomyoma Type of study: Prognostic_studies / Risk_factors_studies Limits: Female / Humans Language: En Journal: Cell Rep Year: 2014 Type: Article Affiliation country: Finland
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Full text: 1 Database: MEDLINE Main subject: Uterine Neoplasms / Cyclin-Dependent Kinases / Mediator Complex / Cyclin-Dependent Kinase 8 / Leiomyoma Type of study: Prognostic_studies / Risk_factors_studies Limits: Female / Humans Language: En Journal: Cell Rep Year: 2014 Type: Article Affiliation country: Finland