Multiplexed DNA repair assays for multiple lesions and multiple doses via transcription inhibition and transcriptional mutagenesis.

Nagel, Zachary D; Margulies, Carrie M; Chaim, Isaac A; McRee, Siobhan K; Mazzucato, Patrizia; Ahmad, Anwaar; Abo, Ryan P; Butty, Vincent L; Forget, Anthony L; Samson, Leona D

Nagel, Zachary D; Margulies, Carrie M; Chaim, Isaac A; McRee, Siobhan K; Mazzucato, Patrizia; Ahmad, Anwaar; Abo, Ryan P; Butty, Vincent L; Forget, Anthony L; Samson, Leona D.

Affiliation

Nagel ZD; Department of Biological Engineering, Center for Environmental Health Sciences, Department of Biology, and The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.

Proc Natl Acad Sci U S A ; 111(18): E1823-32, 2014 May 06.

Article in En | MEDLINE | ID: mdl-24757057

Subject(s)

DNA Damage; DNA Repair; Genetic Techniques; Cell Line; DNA End-Joining Repair; DNA Mismatch Repair; Flow Cytometry; Genes, Reporter; Guanine/analogs & derivatives; Guanine/metabolism; High-Throughput Nucleotide Sequencing; Humans; Mutagenesis; Plasmids/genetics; Sequence Analysis, RNA; Transcription, Genetic; Transfection

Key words

disease prevention; flow cytometry; high-throughput sequencing; personalized medicine

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Full text: 1 Database: MEDLINE Main subject: DNA Damage / Genetic Techniques / DNA Repair Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2014 Type: Article

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