Tissue-specific signals control reversible program of localization and functional polarization of macrophages.
Cell
; 157(4): 832-44, 2014 May 08.
Article
in En
| MEDLINE
| ID: mdl-24792964
ABSTRACT
Tissue-resident macrophages are highly heterogeneous in terms of their functions and phenotypes as a consequence of adaptation to different tissue environments. Local tissue-derived signals are thought to control functional polarization of resident macrophages; however, the identity of these signals remains largely unknown. It is also unknown whether functional heterogeneity is a result of irreversible lineage-specific differentiation or a consequence of continuous but reversible induction of diverse functional programs. Here, we identified retinoic acid as a signal that induces tissue-specific localization and functional polarization of peritoneal macrophages through the reversible induction of transcription factor GATA6. We further found that GATA6 in macrophages regulates gut IgA production through peritoneal B-1 cells. These results provide insight into the regulation of tissue-resident macrophage functional specialization by tissue-derived signals.
Full text:
1
Database:
MEDLINE
Main subject:
Tretinoin
/
Gene Expression Regulation
/
Macrophages, Peritoneal
/
GATA6 Transcription Factor
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Cell
Year:
2014
Type:
Article
Affiliation country:
United States