GABAB agonism promotes sleep and reduces cataplexy in murine narcolepsy.

Black, Sarah Wurts; Morairty, Stephen R; Chen, Tsui-Ming; Leung, Andrew K; Wisor, Jonathan P; Yamanaka, Akihiro; Kilduff, Thomas S

Black, Sarah Wurts; Morairty, Stephen R; Chen, Tsui-Ming; Leung, Andrew K; Wisor, Jonathan P; Yamanaka, Akihiro; Kilduff, Thomas S.

Affiliation

Black SW; Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California 94025 and Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University, Nagoya 464-8601, Japan.

J Neurosci ; 34(19): 6485-94, 2014 May 07.

Article in En | MEDLINE | ID: mdl-24806675

Subject(s)

Cataplexy/drug therapy; GABA Agonists/therapeutic use; Narcolepsy/drug therapy; Receptors, GABA-B/drug effects; Sleep/drug effects; Sodium Oxybate/therapeutic use; Animals; Arousal/drug effects; Arousal/physiology; Ataxin-3; Data Interpretation, Statistical; Diphtheria Toxin/genetics; Dose-Response Relationship, Drug; Electroencephalography/drug effects; Electromyography/drug effects; Humans; Intracellular Signaling Peptides and Proteins/genetics; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins/genetics; Neuropeptides/genetics; Nuclear Proteins/genetics; Orexins; Repressor Proteins/genetics; Sleep, REM/drug effects

Key words

GABA; cataplexy; hypocretin; narcolepsy; orexin; therapeutics

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Full text: 1 Database: MEDLINE Main subject: Sleep / Sodium Oxybate / Cataplexy / Receptors, GABA-B / GABA Agonists / Narcolepsy Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Neurosci Year: 2014 Type: Article Affiliation country: Japan

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