Immuno-chemotherapeutic platinum(IV) prodrugs of cisplatin as multimodal anticancer agents.

Wong, Daniel Yuan Qiang; Yeo, Charmian Hui Fang; Ang, Wee Han

Wong, Daniel Yuan Qiang; Yeo, Charmian Hui Fang; Ang, Wee Han.

Affiliation

Wong DY; Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore (Singapore).

Angew Chem Int Ed Engl ; 53(26): 6752-6, 2014 Jun 23.

Article in En | MEDLINE | ID: mdl-24844571

Subject(s)

Antineoplastic Agents/chemistry; Cisplatin/chemistry; Platinum/chemistry; Prodrugs/chemistry; Antineoplastic Agents/toxicity; Cell Line, Tumor; Cell Survival/drug effects; Cisplatin/toxicity; Coordination Complexes/chemistry; Coordination Complexes/toxicity; Humans; Immunity, Innate/drug effects; Killer Cells, Natural/drug effects; Killer Cells, Natural/immunology; MCF-7 Cells; Macrophages/drug effects; Macrophages/immunology; Prodrugs/toxicity; Receptors, Formyl Peptide/antagonists & inhibitors; Receptors, Formyl Peptide/metabolism; Receptors, Lipoxin/antagonists & inhibitors; Receptors, Lipoxin/metabolism

Key words

antitumor agents; cisplatin; drug targeting; peptides; platinum

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Full text: 1 Database: MEDLINE Main subject: Platinum / Prodrugs / Cisplatin / Antineoplastic Agents Limits: Humans Language: En Journal: Angew Chem Int Ed Engl Year: 2014 Type: Article

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