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Effect of general anesthesia in infancy on long-term recognition memory in humans and rats.
Stratmann, Greg; Lee, Joshua; Sall, Jeffrey W; Lee, Bradley H; Alvi, Rehan S; Shih, Jennifer; Rowe, Allison M; Ramage, Tatiana M; Chang, Flora L; Alexander, Terri G; Lempert, David K; Lin, Nan; Siu, Kasey H; Elphick, Sophie A; Wong, Alice; Schnair, Caitlin I; Vu, Alexander F; Chan, John T; Zai, Huizhen; Wong, Michelle K; Anthony, Amanda M; Barbour, Kyle C; Ben-Tzur, Dana; Kazarian, Natalie E; Lee, Joyce Y Y; Shen, Jay R; Liu, Eric; Behniwal, Gurbir S; Lammers, Cathy R; Quinones, Zoel; Aggarwal, Anuj; Cedars, Elizabeth; Yonelinas, Andrew P; Ghetti, Simona.
Affiliation
  • Stratmann G; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.
  • Lee J; Center for Mind and Brain, University of California, Davis, CA, USA.
  • Sall JW; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.
  • Lee BH; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.
  • Alvi RS; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.
  • Shih J; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.
  • Rowe AM; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.
  • Ramage TM; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.
  • Chang FL; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.
  • Alexander TG; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.
  • Lempert DK; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.
  • Lin N; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.
  • Siu KH; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.
  • Elphick SA; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.
  • Wong A; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.
  • Schnair CI; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.
  • Vu AF; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.
  • Chan JT; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.
  • Zai H; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.
  • Wong MK; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.
  • Anthony AM; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.
  • Barbour KC; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.
  • Ben-Tzur D; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.
  • Kazarian NE; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.
  • Lee JY; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.
  • Shen JR; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.
  • Liu E; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.
  • Behniwal GS; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.
  • Lammers CR; Department of Anesthesia and Pain Medicine, University of California, Davis, CA, USA.
  • Quinones Z; Department of Anesthesia and Pain Medicine, University of California, Davis, CA, USA.
  • Aggarwal A; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.
  • Cedars E; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.
  • Yonelinas AP; Department of Psychology, University of California, Davis, CA, USA.
  • Ghetti S; Department of Psychology, Center for Mind and Brain, University of California, Davis, CA, USA.
Neuropsychopharmacology ; 39(10): 2275-87, 2014 Sep.
Article in En | MEDLINE | ID: mdl-24910347
ABSTRACT
Anesthesia in infancy impairs performance in recognition memory tasks in mammalian animals, but it is unknown if this occurs in humans. Successful recognition can be based on stimulus familiarity or recollection of event details. Several brain structures involved in recollection are affected by anesthesia-induced neurodegeneration in animals. Therefore, we hypothesized that anesthesia in infancy impairs recollection later in life in humans and rats. Twenty eight children ages 6-11 who had undergone a procedure requiring general anesthesia before age 1 were compared with 28 age- and gender-matched children who had not undergone anesthesia. Recollection and familiarity were assessed in an object recognition memory test using receiver operator characteristic analysis. In addition, IQ and Child Behavior Checklist scores were assessed. In parallel, thirty three 7-day-old rats were randomized to receive anesthesia or sham anesthesia. Over 10 months, recollection and familiarity were assessed using an odor recognition test. We found that anesthetized children had significantly lower recollection scores and were impaired at recollecting associative information compared with controls. Familiarity, IQ, and Child Behavior Checklist scores were not different between groups. In rats, anesthetized subjects had significantly lower recollection scores than controls while familiarity was unaffected. Rats that had undergone tissue injury during anesthesia had similar recollection indices as rats that had been anesthetized without tissue injury. These findings suggest that general anesthesia in infancy impairs recollection later in life in humans and rats. In rats, this effect is independent of underlying disease or tissue injury.
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Full text: 1 Database: MEDLINE Main subject: Recognition, Psychology / Memory, Long-Term / Anesthesia, General Type of study: Clinical_trials / Prognostic_studies Limits: Animals / Child / Female / Humans / Male Language: En Journal: Neuropsychopharmacology Journal subject: NEUROLOGIA / PSICOFARMACOLOGIA Year: 2014 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: Recognition, Psychology / Memory, Long-Term / Anesthesia, General Type of study: Clinical_trials / Prognostic_studies Limits: Animals / Child / Female / Humans / Male Language: En Journal: Neuropsychopharmacology Journal subject: NEUROLOGIA / PSICOFARMACOLOGIA Year: 2014 Type: Article Affiliation country: United States