GluN2B N-methyl-D-aspartic acid receptor subunit mediates atorvastatin-Induced neuroprotection after focal cerebral ischemia.

Gutierrez-Vargas, Johanna Andrea; Muñoz-Manco, Juan Ignacio; Garcia-Segura, Luis Miguel; Cardona-Gómez, Gloria Patricia

Gutierrez-Vargas, Johanna Andrea; Muñoz-Manco, Juan Ignacio; Garcia-Segura, Luis Miguel; Cardona-Gómez, Gloria Patricia.

Affiliation

Gutierrez-Vargas JA; Cellular and Molecular Neurobiology Area, Group of Neuroscience of Antioquia, Faculty of Medicine, SIU, University of Antioquia, Medellín, Colombia.

J Neurosci Res ; 92(11): 1529-48, 2014 Nov.

Article in En | MEDLINE | ID: mdl-24939000

Subject(s)

Anticholesteremic Agents/therapeutic use; Brain Ischemia/drug therapy; Heptanoic Acids/therapeutic use; Pyrroles/therapeutic use; Receptors, N-Methyl-D-Aspartate/metabolism; Animals; Anticholesteremic Agents/pharmacology; Atorvastatin; Brain Ischemia/complications; Brain Ischemia/pathology; Cells, Cultured; Cerebral Cortex/cytology; Disease Models, Animal; Embryo, Mammalian; Heptanoic Acids/pharmacology; Male; Maze Learning; Nerve Tissue Proteins/metabolism; Nervous System Diseases/drug therapy; Nervous System Diseases/etiology; Piperidines/pharmacology; Piperidines/therapeutic use; Platelet Aggregation Inhibitors/pharmacology; Platelet Aggregation Inhibitors/therapeutic use; Pyrroles/pharmacology; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate/genetics; Recovery of Function/drug effects; Somatosensory Cortex/drug effects; Time Factors

Key words

BDNF; atorvastatin; cerebral ischemia, GluN2B; neuroprotection; synaptic plasticity

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Full text: 1 Database: MEDLINE Main subject: Pyrroles / Brain Ischemia / Receptors, N-Methyl-D-Aspartate / Heptanoic Acids / Anticholesteremic Agents Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: J Neurosci Res Year: 2014 Type: Article Affiliation country: Colombia

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