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Rapid access to renal transplant waiting list in children: impact of patient and centre characteristics in France.
Hogan, Julien; Savoye, Emilie; Macher, Marie-Alice; Bachetta, Justine; Garaix, Florentine; Lahoche, Annie; Ulinski, Tim; Harambat, Jérôme; Couchoud, Cécile.
Affiliation
  • Hogan J; REIN Registry, Agence de la Biomédecine, La Plaine Saint-Denis Cedex, France.
  • Savoye E; REIN Registry, Agence de la Biomédecine, La Plaine Saint-Denis Cedex, France.
  • Macher MA; REIN Registry, Agence de la Biomédecine, La Plaine Saint-Denis Cedex, France Robert Debré University Hospital, Paris, France.
  • Bachetta J; HFME, Lyon University Hospital, Lyon, France.
  • Garaix F; La Timone, Marseille University Hospital, Marseille, France.
  • Lahoche A; Jeanne de Flandre, Lille University Hospital, Lille, France.
  • Ulinski T; Trousseau University Hospital, Paris, France.
  • Harambat J; REIN Registry, Agence de la Biomédecine, La Plaine Saint-Denis Cedex, France Bordeaux University Hospital, Bordeaux, France.
  • Couchoud C; REIN Registry, Agence de la Biomédecine, La Plaine Saint-Denis Cedex, France.
Nephrol Dial Transplant ; 29(10): 1973-9, 2014 Oct.
Article in En | MEDLINE | ID: mdl-24981582
ABSTRACT

BACKGROUND:

Major inequalities in access to renal transplant waiting lists have been demonstrated among adult patients both in the USA and Europe. In this French nationwide study, we sought to ascertain the influence of patient and centre characteristics.

METHODS:

We included all children (<18 years) in the French End-Stage Renal Disease National Registry, who started renal replacement therapy (RRT) between 1 January 2002 and 31 December 2011. The primary outcome was the probability of being listed within 6 months after starting RRT. Hierarchical logistic regression models were used to study the association between the patient or the centre characteristics and the outcome. Centre effects were assessed by studying the centre-level residual variance.

RESULTS:

A total of 614 incident patients treated in 54 centres were included; 421 (68.6%) were listed within 6 months after starting RRT. A higher risk of not being listed was found in patients younger than 2 years or with a renal disease with a high risk of recurrence after transplantation [odds ratio (OR) 2.61; 95% confidence interval (CI) 1.37-4.97]. We found a significant vintage effect the probability of not being listed decreased over time (OR per 1 year +0.83, 95% CI 0.74-0.94). Although we found no significant gender effect, a trend towards disfavouring girls persisted over the study period. We found a significant centre effect that remained after adjusting for patient characteristics. However, none of the centre characteristics that we studied (centre size, pre-emptive transplantation program, paediatric versus adult centres and the proportion of patients on the waiting list placed on inactive status during the first month after listing) explained this variability.

CONCLUSIONS:

Our study confirms inequalities among children in rapid access to the renal transplant waiting list and shows that patient and centre characteristics play a role in these inequalities. Further studies focusing on the organization and practices of the centres are needed to explain the remaining variability.
Subject(s)
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Full text: 1 Database: MEDLINE Main subject: Waiting Lists / Kidney Transplantation / Renal Replacement Therapy / Patient Selection / Healthcare Disparities / Health Services Accessibility / Kidney Failure, Chronic Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Country/Region as subject: Europa Language: En Journal: Nephrol Dial Transplant Journal subject: NEFROLOGIA / TRANSPLANTE Year: 2014 Type: Article Affiliation country: France

Full text: 1 Database: MEDLINE Main subject: Waiting Lists / Kidney Transplantation / Renal Replacement Therapy / Patient Selection / Healthcare Disparities / Health Services Accessibility / Kidney Failure, Chronic Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Country/Region as subject: Europa Language: En Journal: Nephrol Dial Transplant Journal subject: NEFROLOGIA / TRANSPLANTE Year: 2014 Type: Article Affiliation country: France