Mutations within the conserved NS1 nuclear export signal lead to inhibition of influenza A virus replication.

Tynell, Janne; Melén, Krister; Julkunen, Ilkka

Tynell, Janne; Melén, Krister; Julkunen, Ilkka.

Affiliation

Tynell J; Virology Unit, Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare (THL), Mannerheimintie 166, FIN-00300 Helsinki, Finland. janne.tynell@thl.fi.

Virol J ; 11: 128, 2014 Jul 14.

Article in En | MEDLINE | ID: mdl-25023993

Subject(s)

Conserved Sequence; Influenza A virus/genetics; Mutation; Nuclear Export Signals/genetics; Viral Nonstructural Proteins/genetics; Virus Replication/genetics; Amino Acid Sequence; Amino Acid Substitution; Animals; Cell Line; Cell Nucleus/metabolism; Cleavage And Polyadenylation Specificity Factor/metabolism; Cytoplasm/metabolism; Humans; Influenza, Human/virology; Interferon-gamma/biosynthesis; Karyopherins/metabolism; Models, Molecular; Protein Binding; Protein Conformation; Protein Transport; Receptors, Cytoplasmic and Nuclear/metabolism; Viral Nonstructural Proteins/chemistry; Exportin 1 Protein

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Full text: 1 Database: MEDLINE Main subject: Influenza A virus / Virus Replication / Viral Nonstructural Proteins / Conserved Sequence / Nuclear Export Signals / Mutation Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Virol J Journal subject: VIROLOGIA Year: 2014 Type: Article Affiliation country: Finland

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