Mitoquinone restores platelet production in irradiation-induced thrombocytopenia.

Ramsey, Haley; Zhang, Qi; Wu, Mei X

Ramsey, Haley; Zhang, Qi; Wu, Mei X.

Affiliation

Ramsey H; Department of Dermatology, Wellman Center for Photomedicine, Massachusetts General Hospital (MGH), Harvard Medical School (HMS) , Boston , MA and.

Platelets ; 26(5): 459-66, 2015.

Article in En | MEDLINE | ID: mdl-25025394

Subject(s)

Organophosphorus Compounds/pharmacology; Thrombocytopenia/blood; Thrombocytopenia/etiology; Thrombopoiesis/drug effects; Thrombopoiesis/radiation effects; Ubiquinone/analogs & derivatives; Animals; Antioxidants/metabolism; Blood Platelets/metabolism; Bone Marrow/metabolism; Cell Lineage/genetics; Disease Models, Animal; Immediate-Early Proteins/genetics; Immediate-Early Proteins/metabolism; Megakaryocytes/drug effects; Megakaryocytes/metabolism; Megakaryocytes/radiation effects; Membrane Potential, Mitochondrial/drug effects; Mice; Mice, Knockout; Mitochondria/metabolism; Reactive Oxygen Species/metabolism; Superoxides/metabolism; Thrombocytopenia/drug therapy; Ubiquinone/pharmacology; Whole-Body Irradiation

Key words

Megakaryocytes; Mitoquinone; Reactive Oxygen Species; Thrombocytopenia

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Full text: 1 Database: MEDLINE Main subject: Organophosphorus Compounds / Thrombocytopenia / Ubiquinone / Thrombopoiesis Limits: Animals Language: En Journal: Platelets Journal subject: HEMATOLOGIA Year: 2015 Type: Article

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